The case summarized: New research shows that fat cells can remember what it was like to have obesity, which can explain why it is difficult to keep the weight down after weight loss. The study shows that the fat cells are changed by obesity, and that this change does not disappear even if the pounds do. Researchers believe that this knowledge can be used to develop new treatment methods for obesity. Prevention of obesity and obesity is important, as it can be difficult to lose weight and stay there, once you have become overweight. The summary is made by a Ki service from Openai. The content is quality assured by news’s journalists before publishing. Ida Kristine Kløverud has been great all her life. Already in primary school she struggled with overweight, and later, obesity. She has tried everything to lose weight. – Powder cure. Soup cure. Crispbread cure … I have tried such appetite -reducing things from health food. I have tried to live vegan … several times she lost a few pounds, then go up again. Photo: Private in 2011 she got obesity surgery. The doctors remove parts of the stomach and gut. In the next year, she crashed from nearly 200 kilos to less than 70 kilos. But the roller coaster didn’t end it. – Even after the operation, I managed to put on again, she says. What Kløverud tells about is well known as the jojo effect. You manage to lose weight, but then it doesn’t take long for the pounds to creep again. – You feel failed. You try to keep your food healthy, but you don’t want to live on the salad for the rest of your life, like. Then you go up again, she says. But now researchers have found a possible explanation of what Kløverud and many others are experiencing. Changing obesity – one reason why it is difficult to keep the weight down after weight loss is that the fat cells remember what it was like to have obesity, and that they are probably trying to get back to it. That’s what Professor Ferdinand von Meyenn says to news. He and Laura Hinte have been part of the research team behind the study. First, samples were taken of the fat cells of people during an obesity operation. Then the researchers compare these with samples that were taken after they had lost weight, two years after surgery. In addition, they saw the ridge this was different from people who had never been big. Photo: Private analyzes showed that the fat cells were changed by obesity, and that the change did not disappear, even if the pounds did. In the study, published in Nature, the researchers also describe the hills that previously had obesity put on faster than others when they got a lot of fat food. This indicates that the changes cause the cells to change sick as a response to a “obesity -promoting society” like ours, according to the researchers. – This means that you have to fight against fat memory to keep weight down, explains von Meyenn. Dangerous weight gain Johan Fernø is researching our fat at Haukeland University Hospital in Bergen. He explains that the study shows that obesity can turn on inflammatory genes in the fat cells. – It is interesting that these genes remain screwed, even after losing weight. It is believed that this is a reason for increasing weight again, but you do not quite understand the mechanism behind. Photo: Haukeland University Hospital / news Fernø says it is important to try to go down for people who have obesity to reduce companions, such as diabetes. But it is discussed in the academic environment if you do not have such diseases, the goal should rather be to try to avoid further weight, instead of losing itself. – It may seem to be more dangerous to gain weight to the second and three weight. Fat epigenetic memory Photo: Nadir Mohammad Alam / news We are born with a set of genes found in all our cells. You have the same DNA in the cells of the brain, heart and knee. But only some of the genes are active in each cell type. Other genes are permanently turned off. These active genes in a cell can be affected by factors such as diet, stress, sleep and physical activity. At the molecular level, this occurs at epigenetic changes, where small chemical compounds attach to the DNA and help control the gene activity. Every day, the epigenetic changes in the body occur that cause genes to turn on and off. Some of the changes are more or less permanent, such as in the fat cells. When you gain weight, your fat cells get bigger. At the same time, there is an epigenetic change around genes involved in inflammation (a form of inflammatory reaction) and fibrosis (tissue destroyed by an inflammatory process is replaced by connective tissue). In obesity, the beneficial functions of the fat cells are reduced. While the unfavorable functions, such as too much inflammation, are increased. The problem is that it looks like the negative changes remain changing even when you lose weight. That way, the fat cells remember the “unhealthy” way of functioning. These changes in the fat cells can make you lose weight more easily after you have slimmed down. The effect in the fat can also spread to other organs and help you get more follower diseases such as diabetes 2 and cardiovascular disease. (Source: Johan Fernø/SNL/Wikipedia) He says it may be possible to use the knowledge of fat memory to work out new ways of treating obesity. But Færnø says that this is also important because many people with obesity experience being stigmatized by both society in general, and doctors and health workers. – It is important to recognize obesity as a biological phenomenon. Having obesity is not about being a bad person or not having willpower. There are very strong biological mechanisms there and counteract you, if you try to reduce your body weight. Making prevention even more important Ingrid Sørdal Følling is a researcher at the Regional Center for Obesity Research at St. Olavs Hospital. She is concerned that society does something to avoid so many of us getting overweight and obesity. She thinks the new research is another argument for just that. – You have to prevent you from getting into that condition, because it is so difficult when you are there first. It is incredibly difficult. Photo: Sverre Lilleeng / news She has a lot of experience from researching patients. Some of them have also taken obesity surgery. – You quickly lose weight in the first year. Then it stabilizes after two years and then it can start to go up again. Therefore, she would like to see how long the fat cells remember the obesity they have experienced. Ferdinand von Meyenn explains that he has no answer to it yet. – But, because the fat cells in humans live for about ten years, it is possible that the memory is preserved in the fat for the same time. It can have consequences for how long you follow up obesity patients. – Now we say that you have to follow up well and closely for one year. But maybe you have to follow up even further, says Følling at St. Olavs Hospital. Also, for a couple of years, Ida Kristine Kløverud must be a new grip. She started syringes with liraglutide, a medicine that reduces appetite. After a year, she managed to reach her goal. But what happened after she quit the syringes, she hadn’t imagined. Photo: Egil Trones Christiansen / news instead of struggling down to keep the weight down, she has now had trouble getting enough nutrition. She thinks it is important to get more focus on the mental side of obesity and obesity. – The hat is very important in the whole process. Published 12.03.2025, at. 21.35
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